Francisco Lázaro-Diéguez  (Barakaldo, Spain, 1977)

 

  I started my research as an undergraduate student in the laboratory of Jaime Renau-Piqueras (Hospital La Fe, Valencia, Spain) working in the field of the fetal alcohol syndrome. As a graduate student in the Gustavo Egea Lab (University of Barcelona, Spain) I focused my studies in 1) the implication of the actin filaments in the maintenance of the Golgi apparatus ultrastructure, ionic homeostasis and post-Golgi traffic and 2) the development of a cellular model to address the mechanisms of protein degradation of an actin aggresome/Hirano-like body. During this period I specialized in fluorescence and electron microscopy techniques.


   The goal of my present research in the Anne Müsch Lab (Albert Einstein College of Medicine, Bronx, NY), is the role of the serine/threonine kinase Par1b in cell division for the establishment of hepatocytic vs. columnar polarity in epithelial cells and the mechanisms of post-Golgi traffic for apical and basolateral cargo in hepatocyte-derived cells. Multi-color confocal live imaging, FRAP, FRET and TIRF microscopy are the main techniques I have been using for this purpose.